You don't need to remove the isimple, you do need to unplug or remove your ipod. That is all!!! and yes it will draw it down in in about 4-5 days. I ran my plug out of the bag, and in between the seats for my wife. I put a leather fanny pack on the back of my back rest and the cable sits there. We hook it to our iphones and play pandora from there and use the gps and it works awesome.
You can buy a second cord if you want and run it to the front bars, 2 out ports on the isimple.
If you have an iphone 5 you can get a 30 pin to lightning adapter and I put heat shrink on it, works awesome.