One of John Stossel's shows years ago he talked about cholesterol and he said that for buildup to occur you had to have high blood pressure as well as high cholesterol. The high bp damages the vessels in spots and the buildup in the arteries happens at the damaged part. I don't know. I'm sure there's more to the story. In my case my heart arteries have buildup almost evenly through the entire length including the capillaries so there is something else going on. My cholesterol has almost always been just over 200 total but my ratio of HDL/LDL hasn't been in the desired range. The highest it has ever been is 238 and the lowest I remember is 188 when I was walking a lot. I used to be 6' tall but I've shrunk a couple inches in my old age I guess due to collapsing back discs. And I'm built like a football lineman with a weight of 260 at my heaviest and now at 225. I have exercised periodically all my life, tennis, jogging, walking, weigh lifting, as well as pushups, sit-ups, squats, arm curls and pullovers on my Total Gym. The last 5 are what I do now. Walking a lot has been impossible due to my severe arthritic hip. Getting old sucks! Thinking about a hip joint replacement. Based on my limited experience and knowledge, I highly recommend taking Vitamin K2 supplements whether or not you know you have clogged arteries.